A Microfluidic Device for Exposing Tumor Biopsy Tissue to Multiple Drugs
نویسندگان
چکیده
This paper reports a novel and practical microfluidic approach for culturing live tumor biopsies and multiplexing their exposure to chemotherapy drugs. Our microfluidic device offers 80 individually addressable streams which enables stimulation of multiple areas on a biopsy tissue and allows explant culture of a full core biopsy tissue while preserving the tumor microenvironment. Biopsy tissues from mouse livers were used to provide data including staining of distinct micro-domains on single biopsy tissues and intracellular delivery. Our results demonstrate the feasibility of a novel preclinical paradigm with great potential for predicting drug responses in cancer patients.
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